Cell-free systems for synthetic cells, on-demand biomanufacturing, molecular sensing, and education

Presented by: Michael Jewett
Northwestern University
Featured Talk

Abstract

MICHAEL JEWETT
Cell-free systems for synthetic cells, on-demand biomanufacturing, molecular sensing, and education

Cell-free biology is the activation of complex biological processes without using intact living cells. While used for more than 50 years across the life sciences as a foundational research tool, a recent technical renaissance has made possible high-yielding cell-free gene expression systems (>g protein/L), the development of cell-free platforms from non-model organisms, and multiplexed strategies for rapidly assessing biological design. These advances provide exciting opportunities to profoundly transform synthetic biology through new approaches to model-driven design of genetic circuits, fast and portable sensing of compounds, on demand biomanufacturing, building cells from the bottom up, and next-generation educational kits. Here we describe our recent efforts to transform cell-free biotechnology.

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Premiered March 15, 2021